Joe Gomez returns to the Liverpool defence in place of Ibrahima Konate, who is not involved. Konate has been named in the France squad for the World Cup.
Jordan Henderson, who has been named in England’s World Cup squad, is not involved.
Midfielder Ben Doak, who turned 17 on Friday, is on the bench.
Liverpool XI: Alisson, Gomez, Fabinho, Van Dijk, Thiago, Firmino, Salah, Elliott, Robertson, Nunez, Alexander-Arnold.
Nathan Jones starts his Southampton reign by making a number of changes.
Theo Walcott and Ainsley Maitland-Niles drop to the bench following the 4-1 home defeat to Newcastle last week.
Croatia defender Duje Caleta-Car and forward Adam Armstrong are among those returning to the side.
Southampton XI: Bazunu, Caleta-Car, Ward-Prowse, A Armstrong, Adams, Perraud, S Armstrong, Salisu, Elyounoussi, Bella-Kotchap, Lavia.